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项光亚 教授 |
发布时间:2020-12-29 点击次数: |
项光亚 教授 职称职务:教授/博士生导师 学科专业:药剂学 所属学院:药学院 E - mail: gyxiang1968@hotmail.com 学习与工作经历: 1986.9-1990.7 华东师范大学/化学 学士 1992.9-1995.7 武汉大学/有机化学 硕士 1997.9-2000.7 华中科技大学/劳动卫生与环境卫生 博士
1990.7-1992.9 湖北省黄梅一中化学教研室 教师 1995.7-1997.7 同济医科大学药学院 助教 1997.8—2003.7 华中科技大学同济医学院药学院 讲师 2001.11-2002.10 德国Tuebingen大学有机化学研究所 博士后 2006.8-2007.8 美国俄亥俄州立大学药学院 访问学者 2003.8-2008.10 华中科技大学同济医学院药学院 副教授 2008.11-至今 华中科技大学同济医学院药学院 教授
研究领域 (1)脂质体药物 (2)靶向药物 (3)药物合成工艺
承担课题 • NSFC:叶酸靶向荧光/磁共振多功能脂质体纳米探针的制备及性能研究(2008-2010) 针对肿瘤组织和肿瘤新生血管的多靶点阿霉素脂质体给药系统研究(2011-2013) • 教育部新世纪优秀人才支持计划项目:叶酸靶向脂质体研究The studies of Folate-targeted liposomes(2009-2011) • 武汉市科技攻关重点项目:盐酸巴尼地平的研发 • 湖北省自然科学基金重点项目:以PAMAM为载体的靶向荧光磁共振肿瘤诊断显像剂研究 • ………
论文与获奖情况 • 在国内外学术期刊发表论文 50 余篇,其中SCI/EI收录 20余篇,SCI累计他引100余次。
代表性论著 1. Chang Yang, Lun Ma, Jason Maley, Ramaswami Sammynaiken,Renfei Feng,Guangya Xiang, Wei Che,Photoluminescence and X-Ray Excited Luminescence from Glutathione-Stabilized Gold Nanoparticles,Journal of Biomedical Nanotechnology,2013,Accepted. 2. Jian Li, Yifei Huang, Lei Huang, Lei Ye, Zhou Zhou, Guangya Xiang, Li Xu, Determination of imatinib mesylate and compounds by field amplified sample stacking with large volume sample injection capillary electrophoresis, Journal of Pharmaceutical and Biomedical Analysis, 2012,70:26-31 2. Ye, L; Huang, YF; Li; Xiang, GY; Xu, L,Nonaqueous capillary electrophoresis of imatinib mesylate and related substances,Journal of Separation Science,2012,35(16):2108-2113 3. Yao Lu, Nan Ding, Chang Yang, Lei Huang, Jian Liu, and Guangya Xiang,Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation,Journal of Liposome Research, 2012,22(2):110-119 4. Xianmei Shang*, Nan Ding, Guangya Xiang*,Novel di-n-butyltin(IV) derivatives: Synthesis, high levels of cytotoxicity in tumor cells and the induction of apoptosis in KB cancer cells,European Journal of Medicinal Chemistry,2012,48:305-312 5. Nan Ding,Yao Lu, Robert J Lee, Chang Yang, Lei Huang, Jian Liu, Guangya Xiang,Folate receptor targeted fluorescentparamagnetic bimodal liposomes for tumor imaging,International Journal of Nanomedicine,2011,6:2513-2520 6. Guangya Xiang*,Jun Wu,Yanhui Lu, Zhilan Liu,Robert J Lee,Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes,International Journal of Pharmaceuticals,2008,356:29-36 7. Yanhui Lu, Jun Wu,Jianmei Wu,Mefsin Gonit, Xiaojuan Yang, Alice Lee, Guangya Xiang, Hong Li, Shujun Liu, Guido Marcucci, Manohar Rantnam,and Robert J Lee, Role of Formulation Composition in Folate Receptor-Targeted Liposomal Doxorubicin Delivery to Acute Myelogenous Leukemia Cells,Molecular Pharmaceutics,2007,4(5):707-712 8. Qi Zhang, Guang Ya Xiang* , Youjiu Zhang, et al. Increase of Doxorubicin Sensitivity for Folate Receptor Positive Cells when given as the Prodrug N-(phenylacetyl) doxorubicin in Combination with Folate-conjugated PGA,Journal of Pharmaceutical Sciences,2006, 2006, 95(10):2266-75 |