甘璐　教授

职称职务：教授/博士生导师   纳米药物制剂研发部 

学科专业：分子生物物理

E - mail： lugan@mail.hust.edu.cn

学习与工作经历：

1996获华中农业大学食品工程学士学位

2001获华中农业大学食品加工及储藏工程博士学位

2001.7-2003.6华中科技大学生物医学工程博士后流动站 博士后

2003.7-至今 华中科技大学生命科学与技术学院

2006.5-2007.9 美国圣路易斯华盛顿大学医学院 博士后

2007.10-2009.5 美国明尼苏达大学Masonic癌症中心 博士后

研究领域

（1）肿瘤信号转导

（2）纳米肿瘤学

承担课题

•       NSFC：MEKK1-FOXO1信号通路在前列腺癌转移中的作用和机制研究 (2011-2013)

•       NSFC青年基金：活性氧调控胰岛素分泌的分子机制（2006-2008）

•       国家重大科学研究计划：基于纳米技术的肝癌早期诊断的研究课题三：肝癌影像学早期诊断靶标纳米对比剂的生物特性及其成像技术 (2011-2015)

•       湖北省科技攻关项目: 大蒜素纳米乳注射液的研制 (2007-2009)

论文与获奖情况

•       发表SCI论文20余篇，累计他引200余次

•       获湖北省科技进步二等奖1项

•       参编专著2部（《纳米药物》和《硒的化学、生物化学及其在生命科学中的应用》）

代表性论著

1. Zhen Zhang, Xiaoqin Xiong, Jiangling Wan, Ling Xiao, Lu Gan*, Youmei Feng, Huibi Xu, Xiangliang Yang*.Cellular uptake and intracellular trafficking of PEG-b-PLA polymeric micelles.Biomaterials, 2012, 33(29): 7233-7240.

2. Chun Zhang*, Ying Liu, Xiaoqin Xiong, Lianhui Peng, Lu Gan*, Chuanfeng Chen*, Huibi Xu. Three-dimensional nanographene based on triptycene: synthesis and its application in fluorescence imaging. Organic Letters, 2012, 14(23): 5912-5915.

3. Ling Xiao, Xiaoqin Xiong, Xiaohui Sun, Yanhong Zhu, Hao Yang, Huabing Chen, Lu Gan*, Huibi Xu, Xiangliang Yang*.Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials, 2011, 32(22) :5148-5157.

4. Lu Gan*, Jianling Wang, Huibi Xu, Xiangliang Yang. Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling. Prostate, 2011, 71(11): 1158-1166.

5. Ruizhen Liu, Lu Gan*, Xiangliang, Huibi Xu. Chitosan as a condensing agent induces high gene transfection efficiency and low cytotoxicity of liposome. Journal of Bioscience and Bioengineering, 2011, 111(1): 98-103.

6. Bo Liu, Xiaohui Sun, Yanhong Zhu, Lu Gan*, Huibi Xu, Xiangliang Yang. Biphasic effects of H₂O₂ on BK_Ca channels. Free Radiccal Research, 2010, 44(9): 1004-1012.

7. Lu Gan, Ping Liu, Huarui Lu, Shuai Chen, Jianbo Yang, JB McCarthy, Karen E. Knudsen, Haojie Huang. Cyclin D1 promotes anchorage-independent cell survival by inhibiting FOXO-mediated anoikis. Cell Death and Differentiation, 2009, 16 (10): 1408-1417.

8. Lu Gan, Shuai Chen, Yuwei Wang, Akira Watahiki, Laura Bohrer, Zhen Sun, Yuzhuo Wang, Haojie Huang. Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer. Cancer Research, 2009, 69(21): 8386-8394.

9. Bo Liu, Lu Gan*, Xiaohui Sun, Yanhong Zhu, Zhihua Tong, Huibi Xu, Xiangliang Yang*. Biochimica et Biophysica Acta: Biomembranes, 2009, 1788 (10): 2174-2182.

10. Lu Gan, Xiangliang Yang, Qiong Liu, Huibi Xu. Inhibitory effects of thioredoxin reductase antisense RNA on the growth of human hepatocellular carcinoma cells. Journal of Cellular Biochemistry, 2005, 96(3): 653-664.

11. Lu Gan, Shenghua Zhang, Xiangliang Yang, Huibi Xu. Immunomodulation and antitumor activity by a polysaccharide protein complex from Lycium barbarum. International Immunopharmacology, 2004, 4(4): 563-568.

12. Lu Gan, Shenghua Zhang, Qiong Liu, Huibi Xu. A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells. European Journal of Pharmacology, 2003, 471(3): 217-222.

13. Lu Gan, Qiong Liu, Huibi Xu, Yushan Zhu, Xiangliang Yang. Effects of selenium overexposure on glutathione peroxidase and thioredoxin reductase gene expressions and activities. Biological Trace Element Research, 2002, 89(2):165-175.